Polyderm 4 Mechanism of Action

Pharmacology: Clinical studies have demonstrated the efficacy of betamethasone valerate in the treatment of corticosteroid-responsive dermatoses. When betamethasone valerate was subjected to the Draize patch test, no primary irritation or potential for allergic contact dermatitis occurred.
In vitro antibacterial activity of gentamicin showed it to be bactericidal against a wide variety of gram-positive and gram-negative bacteria. At concentrations 4 mcg/mL or less, gentamicin inhibited 95% strains of Staphylococcus aureus and 70-90% of strains of Escherichia coli and Aerobacter aerogenes. Toxicity studies animals and man revealed no evidence of skin irritation after local application of gentamicin in concentrations higher than that formulated for therapeutic use. Results of the Draize cutaneous patch test in 100 patients indicated that gentamicin was not primary irritant; furthermore, gentamicin has a low index of skin irritation sensitization. Tolnaftate is a potent fungicidal agent against Trychophyton mentagrophyes, Trichophyton rubrum, Microsporum canis, Epidermophyton occosum and Malassezia furfur. Clinical studies have shown the excellent fungicidal effect of tolnaftate in large number of patients with superficial fungal infections. Therapy with tolnaftate has been notable for lack of recurrence. Test of skin sensitivity have shown no signs of local irritation 24 and 48 hours after medication was applied. Clioquinol is effective topical therapy for bactericidal and/or candidial (monilial) infections. Inhibition of candida labicans was obtained with concentrations of 25 mcg/mL. At concentrations of 50 mcg/mL clioquinol completely/inhibited all our four strains of Candida albicans tested. Each component of cream makes a significant contribution to the efficacy of the product in treating infections of mixed etiology.